Collections
NEWS - Timely articles written from a journalistic perspective on hot areas in the bone field.
Vibration Therapy: Does It Have a Future in the Bone Field?
Neil A. Andrews
Clinical trials of vibration therapy, in the form of high-frequency, low-magnitude mechanical stimulation (LMMS), for the treatment of low bone mass are underway, but many questions remain about the potential use of this therapy in the osteoporosis arena. Does LMMS build new bone? If it does, what is the mechanism of action? This news article features interviews with leading experts in the bone field who address these and many other intriguing questions.
[Full Text] [PDF]
PERSPECTIVES - Insightful, thematic reviews of key topics on both the basic science and clinical sides.
Bone Quality and Strontium Ranelate
Georges Boivin
Dr. Boivin reviews recent work documenting the effects of strontium ranelate on bone quality, with a focus on bone biopsies from patients treated with this agent.
[Abstract] [Full Text] [PDF]
COMMENTARIES - Analyses of specific pathbreaking papers appearing in all of the major scientific and medical journals.
Teriparatide: Variations on the Theme of a 2-Year Therapeutic Course
Natalie E. Cusano and John P. Bilezikian
Considering that most patients who will be treated with teriparatide or PTH(1-84) have previously received an antiresorptive drug, what is preferable: to add the osteoanabolic agent to the antiresorptive one or to switch from the antiresorptive drug to the osteoanabolic agent alone? The authors analyze two recent J Clin Endocrinol Metab. studies, one by Cosman et al. and the other by Finkelstein et al., as they attempt to answer this important clinical question.
[Full Text] [PDF]
MEETING REPORTS - Comprehensive examinations of new findings presented at the major bone meetings.
Meeting Report from the IX International Meeting on Cancer Induced Bone Disease
Various Authors
This report includes coverage of the biology and treatment of prostate cancer bone metastasis; cancer-associated fibroblasts; hematopoietic stem cells, cancer stem cells, and the hematopoietic stem cell niche; imaging and proteomics of bone metastasis; and tumor-associated osteoclastogenesis and angiogenesis
[Full Text] [PDF]
NOT TO BE MISSED - Annotations, written by the IBMS BoneKEy editors, on the most important articles published in the literature each month.
Rached et al. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts Cell Metab. 2010 Feb 3;11(2):147-60.
In this report, the authors employ osteoblast-specific deletion of three FoxO proteins, and showed that only FoxO1 is required for proliferation and redox balance in osteoblasts. They also demonstrated that...
[Full Text] [PDF]
ARTICLES - Unique content covering special topics, such as new clinical guidelines.
The Epidemiology of Osteoporosis in Asia
Edith M. Lau
[Full Text] [PDF]
ELECTRONIC LETTERS TO THE EDITOR - Comments submitted by readers in response to original content published on BoneKEy.
All Clinicians Are Bayesians
Robert S. Fredericks
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