Collections
NEWS - Timely articles written from a journalistic perspective on hot areas in the bone field.
SNPs in the Clinic for Fracture Risk Prediction: A Foreseeable Reality or a Distant Dream?
Neil A. Andrews
Will the SNPs identified in genome-wide association studies prove useful for predicting who will fracture? Interviews with top osteoporosis genetics experts suggest an unfinished story.
[Full Text] [PDF]
PERSPECTIVES - Insightful, thematic reviews of key topics on both the basic science and clinical sides.
Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype
Yen K. Luu, Jeffrey E. Pessin, Stefan Judex, Janet Rubin and Clinton T. Rubin
The authors discuss the evidence for the ability of mechanical signals to influence the differentiation of mesenchymal stem cells into the bone or fat lineage. Could these signals form the basis of a new, safe, and non-pharmacologic approach for the prevention of both osteoporosis and obesity?
[Abstract] [Full Text] [PDF]
COMMENTARIES - Analyses of specific pathbreaking papers appearing in all of the major scientific and medical journals.
Should We Be Concerned About Giant Osteoclasts?
Robert R. Recker
A recent New England Journal of Medicine paper reports the presence of giant osteoclasts in patients treated with alendronate. What accounts for this phenomenon, and is it something to worry about? Dr. Recker offers an analysis of this intriguing new study.
[Full Text] [PDF]
MEETING REPORTS - Comprehensive examinations of new findings presented at the major bone meetings.
Advances in Therapeutics: Meeting Report from the 30th Annual Meeting of the American Society for Bone and Mineral Research
Ego Seeman
Dr. Seeman discusses the important advances in therapeutics presented at the last ASBMR meeting in Montréal, including findings on bisphosphonates, SERMs, anti-sclerostin antibody, PTH, strontium ranelate, denosumab, vitamin D, and other agents.
[Full Text] [PDF]
NOT TO BE MISSED - Annotations, written by the IBMS BoneKEy® editors, on the most important articles published in the literature each month.
Kansara et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest. 2009 Apr;119(4):837-51.
While focusing on Wnt-LRP5/LRP6-β-catenin signaling as a major pathway for bone formation, we should not forget that Wnts also have a major impact on the oncogenic process. Wnt inhibitory factor 1 (WIF1) was found to be epigenetically silenced...
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ARTICLES - Unique content covering special topics, such as new clinical guidelines.
The Epidemiology of Osteoporosis in Asia
Edith M. Lau
[Full Text] [PDF]
ELECTRONIC LETTERS TO THE EDITOR - Comments submitted by readers in response to original content published on BoneKEy.
Should we be concerned about bisphosphonate-induced giant osteoclasts in myeloma?
Shmuel Yaccoby and Joshua Epstein
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