CURRENT ISSUE: June 2009
NOTE FROM THE EDITORS
New papers from Odvina et al. and Wang et al. on bone remodeling
Life may or may not imitate art. Remodeling is needed for damage repair but as remodeling balance between the volumes of bone formed and resorbed is negative, every time remodeling occurs bone is lost and structural damage occurs. The question is what is the net effect of suppressing remodeling with accumulation of matrix damage...
Read more about these new research findings in this month's Not To Be Missed!
--The Editors
The Future of Mouse Genetics in Osteoporosis Research
By Cheryl L. Ackert-Bicknell and Clifford J. Rosen
The authors describe new techniques and resources for mouse genetics, including a new mouse genetic map, haplotype association mapping, expression QTL mapping and the Collaborative Cross. A table of useful web-based resources for mouse genetics is also provided.
By Philippe Clézardin
Dr. Clézardin reviews the experimental evidence for direct and indirect inhibitory effects of nitrogen-containing bisphosphonates on soft tissue tumors and visceral metastases. Emerging data from clinical trials of patients with breast cancer is also discussed.
Regulation of Bone Mass: Local Control or Systemic Influence or Both?
By Lance E. Lanyon, Toshihiro Sugiyama, and Joanna S. Price
The authors discuss the role of the mechanostat in bone, and how an understanding of its workings might impact strategies for therapeutic intervention.
By J. Wesley Pike, Mark B. Meyer and Melissa L. Martowicz
Does Rat + Bisphosphonate + Exposed Bone = An Animal Model of ONJ?
By Matthew R. Allen
A recent study from Oral Oncology describes results from an animal model of bisphosphonate-associated osteonecrosis of the jaw. Dr. Allen describes the strengths and limitations of this potential new animal model of the disease.
DID YOU MISS?
The Epidemiology of Osteoporosis in Asia
By Edith M. Lau
Click here for BoneKEy teaching slide set on clinical osteoporosis
1st Advances in Rare Bone Diseases Scientific Conference: October 23-24, 2008
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